Review
Nature Reviews Neuroscience 5, 709-720 (September 2004) | doi:10.1038/nrn1496
Molecular and neuronal substrates for general anaesthetics
Uwe Rudolph1 & Bernd Antkowiak2 About the authors
Abstract
Although general anaesthesia has been of tremendous importance for the development of surgery, the underlying mechanisms by which this state is achieved are only just beginning to be understood in detail. In this review, we describe the neuronal systems that are thought to be involved in mediating clinically relevant actions of general anaesthetics, and we go on to discuss how the function of individual drug targets, in particular GABAA-receptor subtypes, can be revealed by genetic studies in vivo.
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Author affiliations
- Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
- Department of Anaesthesiology, Section of Experimental Anaesthesiology, University of Tübingen, Schaffhausenstr. 113, D-72072 Tübingen, Germany.
Correspondence to: Uwe Rudolph1 Email: rudolph@pharma.unizh.ch
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