Abstract
Functional imaging gives us increasingly detailed information about the location of brain activity. To use this information, we need a clear conception of the meaning of location data. Here, we review methods for reporting location in functional imaging and discuss the problems that arise from the great variability in brain anatomy between individuals. These problems cause uncertainty in localization, which limits the effective resolution of functional imaging, especially for brain areas involved in higher cognitive function.
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References
Worsley, K. J. An overview and some new developments in the statistical analysis of PET and fMRI data. Hum. Brain Mapp. 5, 254–258 (1997).
Grabowski, T. J. et al. Reliability of PET activation across statistical methods, subject groups, and sample sizes. Neuroimage 4, 23–46 (1996).
Brodmann, K. Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues (Barth, Leipzig, 1909).
von Economo, C. & Koskinas, G. N. Die cytoarchitectonic der Hirnrinde des erwachsenen Menschen (Springer, Berlin, 1925).
Sarkissov, S. A. et al. (eds) Atlas of the Cytoarchitectonics of the Human Cerebral Cortex (Medgiz, Moscow, 1955).
Roland, P. E. & Zilles, K. Brain atlases — a new research tool. Trends Neurosci. 17, 458–467 (1994).
Owen, A. M. The role of the lateral frontal cortex in mnemonic processing: the contribution of functional neuroimaging. Exp. Brain Res. 133, 33–43 (2000).
Fischl, B. et al. High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum. Brain Mapp. 8, 272–284 (1999).
Ono, M., Kubik, S. & Abernathey, C. D. Atlas of the Cerebral Sulci (Thieme Medical, New York, 1990).
Tzourio-Mazoyer, N. et al. in Handbook of Medical Imaging: Processing and Analysis (ed. Bankman, I.) 449–463 (Academic, San Diego, 2000).
Watson, J. D. et al. Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging. Cereb. Cortex 3, 79–94 (1993).
Kotter, R. et al. Multimodal characterisation of cortical areas by multivariate analyses of receptor binding and connectivity data. Anat. Embryol. (Berl.) 204, 333–350 (2001).
Roland, P. E. & Zilles, K. Structural divisions and functional fields in the human cerebral cortex. Brain Res. Brain Res. Rev. 26, 87–105 (1998).
Morel, A., Garraghty, P. E. & Kaas, J. H. Tonotopic organization, architectonic fields, and connections of auditory cortex in macaque monkeys. J. Comp. Neurol. 335, 437–459 (1993).
Kaas, J. H. & Hackett, T. A. Subdivisions of auditory cortex and processing streams in primates. Proc. Natl Acad. Sci. USA 97, 11793–11799 (2000).
Rivier, F. & Clarke, S. Cytochrome oxidase, acetylcholinesterase, and NADPH-diaphorase staining in human supratemporal and insular cortex: evidence for multiple auditory areas. Neuroimage 6, 288–304 (1997).
Morosan, P. et al. Human primary auditory cortex: cytoarchitectonic subdivisions and mapping into a spatial reference system. Neuroimage 13, 684–701 (2001).
Wallace, M. N., Johnston, P. W. & Palmer, A. R. Histochemical identification of cortical areas in the auditory region of the human brain. Exp. Brain Res. (in the press).
Amunts, K. & Zilles, K. Advances in cytoarchitectonic mapping of the human cerebral cortex. Neuroimaging Clin. N. Am. 11, 151–169 (2001).
Kaas, J. H. & Collins, C. E. The organization of sensory cortex. Curr. Opin. Neurobiol. 11, 498–504 (2001).
Amunts, K. et al. Broca's region revisited: cytoarchitecture and intersubject variability. J. Comp. Neurol. 412, 319–341 (1999).
Rademacher, J. et al. Probabilistic mapping and volume measurement of human primary auditory cortex. Neuroimage 13, 669–683 (2001).
Rajkowska, G. & Goldman-Rakic, P. S. Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46 and relationship to the Talairach Coordinate System. Cereb. Cortex 5, 323–337 (1995).
Gilissen, E. & Zilles, K. The calcarine sulcus as an estimate of the total volume of human striate cortex: a morphometric study of reliability and intersubject variability. J. Hirnforsch. 37, 57–66 (1996).
Rademacher, J. et al. Topographical variation of the human primary cortices: implications for neuroimaging, brain mapping, and neurobiology. Cereb. Cortex 3, 313–329 (1993).
Penhune, V. B. et al. Interhemispheric anatomical differences in human primary auditory cortex: probabilistic mapping and volume measurement from magnetic resonance scans. Cereb. Cortex 6, 661–672 (1996).
Hall, D. A. et al. Spectral and temporal processing in human auditory cortex. Cereb. Cortex 12, 140–149 (2002).
Lancaster, J. L. et al. Automated Talairach atlas labels for functional brain mapping. Hum. Brain Mapp. 10, 120–131 (2000).
Schormann, T. & Zilles, K. Three-dimensional linear and nonlinear transformations: an integration of light microscopical and MRI data. Hum. Brain Mapp. 6, 339–347 (1998).
Geyer, S., Schleicher, A. & Zilles, K. The somatosensory cortex of human: cytoarchitecture and regional distributions of receptor-binding sites. Neuroimage 6, 27–45 (1997).
Geyer, S., Schleicher, A. & Zilles, K. Areas 3a, 3b, and 1 of human primary somatosensory cortex. Neuroimage 10, 63–83 (1999).
Geyer, S. et al. Areas 3a, 3b, and 1 of human primary somatosensory cortex. Part 2. Spatial normalization to standard anatomical space. Neuroimage 11, 684–696 (2000).
Rademacher, J. et al. Variability and asymmetry in the human precentral motor system. A cytoarchitectonic and myeloarchitectonic brain mapping study. Brain 124, 2232–2258 (2001).
Amunts, K. et al. Brodmann's areas 17 and 18 brought into stereotaxic space — where and how variable? Neuroimage 11, 66–84 (2000).
Roland, P. E. et al. Cytoarchitectonic maps of the human brain in standard anatomical space. Hum. Brain Mapp. 5, 222–227 (1997).
Binkofski, F. et al. Broca's region subserves imagery of motion: a combined cytoarchitectonic and fMRI study. Hum. Brain Mapp. 11, 273–285 (2000).
Bodegard, A. et al. Object shape differences reflected by somatosensory cortical activation. J. Neurosci. 20, RC51 (2000).
Johnsrude, I. et al. Cytoarchitectonic region-of-interest analysis of auditory imaging data. Neuroimage 13, S897 (2001).
Wieshmann, U. C. et al. Combined functional magnetic resonance imaging and diffusion tensor imaging demonstrate widespread modified organisation in malformation of cortical development. J. Neurol. Neurosurg. Psychiatry 70, 521–523 (2001).
Mori, S. et al. In vivo visualization of human neural pathways by magnetic resonance imaging. Ann. Neurol. 47, 412–414 (2000).
Conturo, T. E. et al. Tracking neuronal fiber pathways in the living human brain. Proc. Natl Acad. Sci. USA 96, 10422–10427 (1999).
Duong, T. Q. et al. Spatiotemporal dynamics of the BOLD fMRI signals: toward mapping submillimeter cortical columns using the early negative response. Magn. Reson. Med. 44, 231–242 (2000).
Yoshiura, T. et al. Heschl and superior temporal gyri: low signal intensity of the cortex on T2-weighted MR images of the normal brain. Radiology 214, 217–221 (2000).
Goodyear, B. G. & Menon, R. S. Brief visual stimulation allows mapping of ocular dominance in visual cortex using fMRI. Hum. Brain Mapp. 14, 210–217 (2001).
Kanwisher, N., McDermott, J. & Chun, M. M. The fusiform face area: a module in human extrastriate cortex specialized for face perception. J. Neurosci. 17, 4302–4311 (1997).
Epstein, R. & Kanwisher, N. A cortical representation of the local visual environment. Nature 392, 598–601 (1998).
Downing, P. E. et al. A cortical area selective for visual processing of the human body. Science 293, 2470–2473 (2001).
Epstein, R. et al. The parahippocampal place area: recognition, navigation, or encoding? Neuron 23, 115–125 (1999).
Thompson, P. M. & Toga, A. W. in Handbook of Medical Imaging: Processing and Analysis (ed. Bankman, I.) 569–600 (Academic, San Diego, 2000).
Woods, R. P. et al. Automated image registration: II. Intersubject validation of linear and nonlinear models. J. Comput. Assist. Tomogr. 22, 153–165 (1998).
Ashburner, J. & Friston, K. J. Nonlinear spatial normalization using basis functions. Hum. Brain Mapp. 7, 254–266 (1999).
Fischl, B., Sereno, M. I. & Dale, A. M. Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage 9, 195–207 (1999).
Thompson, P. M. et al. Mathematical/computational challenges in creating deformable and probabilistic atlases of the human brain. Hum. Brain Mapp. 9, 81–92 (2000).
Jezzard, P. & Clare, S. Sources of distortion in functional MRI data. Hum. Brain Mapp. 8, 80–85 (1999).
Woods, R. D. in Handbook of Medical Imaging: Processing and Analysis (ed. Bankman, I.) 491–497 (Academic, San Diego, 2000).
Fox, P. T., Parsons, L. M. & Lancaster, J. L. Beyond the single study: function/location metanalysis in cognitive neuroimaging. Curr. Opin. Neurobiol. 8, 178–187 (1998).
Brett, M., Lancaster, J. & Christoff, K. Using the MNI brain with the Talairach atlas. Neuroimage 13, S85 (2001).
Duncan, J. & Owen, A. M. Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends Neurosci. 23, 475–483 (2000).
D'Esposito, M., Postle, B. R. & Rypma, B. Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies. Exp. Brain Res. 133, 3–11 (2000).
Petersson, K. M. et al. Statistical limitations in functional neuroimaging II. Signal detection and statistical inference. Phil. Trans. R. Soc. Lond. B 354, 1261–1281 (1999).
Friston, K. J. et al. Detecting activations in PET and fMRI: levels of inference and power. Neuroimage 4, 223–235 (1996).
Van Horn, J. D. et al. Mapping voxel-based statistical power on parametric images. Neuroimage 7, 97–107 (1998).
Andreasen, N. C. et al. Sample size and statistical power in [15O]H2O studies of human cognition. J. Cereb. Blood Flow Metab. 16, 804–816 (1996).
Christoff, K. & Gabrielli, J. D. E. The frontopolar cortex and human cognition: evidence for a rostrocaudal hierarchical organization within the human prefrontal cortex. Psychobiology 28, 168–186 (2000).
Talairach, J. & Tournoux, P. Co-planar Stereotaxic Atlas of the Human Brain (Thieme Medical, New York, 1988).
Collins, D. L. 3D Model-Based Segmentation of Individual Brain Structures from Magnetic Resonance Imaging Data. Thesis, McGill Univ., Canada (1994).
Evans, A. C. et al. Anatomical mapping of functional activation in stereotactic coordinate space. Neuroimage 1, 43–53 (1992).
Evans, A. C., Collins, D. L. & Milner, B. An MRI-based stereotactic atlas from 250 young normal subjects. Soc. Neurosci. Abstr. 18, 408 (1992).
Collins, D. L. et al. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J. Comput. Assist. Tomogr. 18, 192–205 (1994).
Duncan, J. et al. A neural basis for general intelligence. Science 289, 457–460 (2000).
Acknowledgements
Many thanks to T. Hackett and M. Petrides for helpful discussions on cytoarchitecture, and to J. Ashburner, S. Baxendale, D. Bor, J. Collins, L. Collins, R. Cools, M. Davis, G. DiGirolamo, J. Duncan, A. Gazanfar, A. Lawrence and T. Marcel for comments on earlier drafts of this paper.
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Brett, M., Johnsrude, I. & Owen, A. The problem of functional localization in the human brain. Nat Rev Neurosci 3, 243–249 (2002). https://doi.org/10.1038/nrn756
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DOI: https://doi.org/10.1038/nrn756