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In addition to their roles in nervous system development, Wnts participate in synaptic maintenance and function and in adult neurogenesis. Here, Inestrosa and Arenas review the latest research on the functions of Wnt signalling in the adult nervous system and potential therapeutic implications.
Astrocytes, like neurons, are organized into networks and exchange information through gap junction channels. Giaume and colleagues discuss the rules that govern communication between astrocytes and how astroglia networks can influence the function of neural networks.
Uhlhaas and Singer outline the evidence that schizophrenia is associated with deficits in neural oscillations. They discuss the possible underlying mechanisms and how these impairments might contribute to the pathophysiology of the disorder.
Sleep improves the consolidation of both declarative and non-declarative memories. Diekelmann and Born discuss the potential mechanisms through which slow wave sleep and rapid eye movement sleep support system and synaptic consolidation.
Karl Friston shows that different global brain theories all describe principles by which the brain optimizes value and surprise. He discusses how these brain theories fit into the free-energy framework, suggesting that this framework might provide a unified account of brain function.
To celebrate the centenary of Brodmann's brain map, Zilles and Amunts review his pioneering work and its legacy. This article reconsiders the original concepts described by Brodmann and the use of his map for interpreting functional and structural neuroimaging data today.
