Abstract

Following CNS injury, in an apparently counterintuitive response, scar tissue formation inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-modulating treatments have become a leading therapeutic goal in the field of spinal cord injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing.

Author affiliations

1. Asya Rolls, Ravid Shechter and Michal Schwartz are at the Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel.

Correspondence to: Michal Schwartz¹ Email: michal.schwartz@weizmann.ac.il

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