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Fluorescent indicators can provide quantitative insights into the spatiotemporal dynamics of signalling molecules released by brain circuits. However, a mismatch between the experimental context and the experimental imaging settings often introduces unexpected errors and biases in such measurements. Appreciating this mismatch should help to arrive at unbiased estimates.
The macaque homologue of the dorsal medial prefrontal cortex tracks the reliability of social information and determines whether this information is used to guide choices during decision making.
Grid cells develop in rats soon after they leave the nest. Here, Ulsaker-Janke et al. show that preventing exposure to straight boundaries from birth delays, but does not prevent, grid cell maturation in adult rats.
A new study shows that, in a numerical judgement task, individuals show differences in neuronal coding of numbers below and above approximately four in the medial temporal lobe.
Architectures in neural networks commonly assume that inference is hierarchical. In this Perspective, Suzuki et al. present the shallow brain hypothesis, a neural processing mechanism based on neuroanatomical and electrophysiological evidence that intertwines hierarchical cortical processing with a massively parallel process to which subcortical areas substantially contribute.
The neuropeptide oxytocin has a vital role in many mammalian social behaviours. Here, Menon and Neumann provide a comprehensive review of the rodent neuronal circuits in which oxytocin acts to regulate the processing of social cues in order to reinforce reproductive and non-reproductive social behaviours.
Data sharing is an essential component of open science practice. The Brain Imaging Data Structure project has pioneered a way to organize neuroimaging and behavioural data that enables easy sharing and reuse. We present experiences from the BIDS project and highlight how standards can promote open science.
Neuron–oligodendroglial interactions modulate neural circuit structure and function in the healthy brain. In this Review, Taylor and Monje describe the accumulating evidence for how glial malignancies subvert and repurpose these powerful neuron–glial interactions to drive glioma pathophysiology.
Following synaptic vesicle exocytosis, synaptotagmin 1 recruits a lipid signalling pathway within the presynaptic plasma membrane that drives local dynamin recruitment and membrane retrieval by endocytosis, thus maintaining membrane homeostasis.
High-resolution maps of biological annotations in the brain are increasingly generated and shared. In this Review, Bazinet and colleagues discuss how brain connectomes can be enriched with biological annotations to address new questions about brain network organization.
In this Journal Club, Nathan Anthony Smith discusses a 2008 paper that documented a link between the noradrenergic modulatory network in the locus coeruleus and cortical astrocytes in vivo.
The prospects for applying dynamical systems theory in neuroscience are changing dramatically. In this Perspective, Durstewitz et al. discuss dynamical system reconstruction using recurrent neural networks to directly infer a formal surrogate from an experimentally probed system and consider its potential for revolutionizing neuroscience.
Song and speech may have distinct roles in human communication. Scott and colleagues describe the mechanisms underlying the production and perception of song and speech, evaluate the evidence for distinct song-processing mechanisms in the human brain, and consider the implications of such specialization.
Synaptic or neuronal activity can trigger transcriptional changes in the nucleus that are important for learning and memory. Tsien, Ma and co-workers here provide a comprehensive review of the complex signalling pathways involved in this excitation–transcription coupling.
A study reports that in the mouse hippocampus, the induction of long-term potentiation is dependent on the structural functions of CaMKII and not its enzymatic activity.
A juvenile hormone-degrading enzyme localized in the insect equivalent of the blood–brain barrier governs which social role, forager or soldier, worker carpenter ants fulfil.
