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In this Review, Miller and Arias summarize recent advances in understanding ESKAPE pathogens, focusing on their molecular epidemiology, clinical impact, emerging mechanisms of resistance and novel therapeutic approaches.
In this Review, Lyons, Tino and colleagues explore the evolution of microbial life on Earth and examine the diversity of early microbial metabolic pathways, their associations with biogeochemical cycles and how they shaped and responded to changing surface environments over billions of years.
In this Review, Mather et al. discuss the role of genome-based approaches in deepening our understanding of both enduring and emerging bacterial foodborne pathogens in the context of evolving global food systems and environmental changes.
In this Review, Özçam and Lynch examine recent findings reporting the interaction between the gut and the airway microbiomes and explore the role of gut–airway crosstalk in human health and respiratory diseases.
This study by Chen et al. reveals that a high-fat diet leads to a predominance of Desulfovibrio species in the gut, correlating with a poor prognosis of breast cancer.
In this Journal Club, Carrie Shaffer discusses a study revealing that infection with CagA-positive Helicobacter pylori strains is associated with an increased risk of developing stomach adenocarcinoma.
In this Journal Club, Yi Shi discusses a paper reporting that influenza virus infection in humans induces broadly cross-reactive and protective antibodies against the viral neuraminidase.
This Genome Watch article discusses the application of sequencing methods for monitoring the rise of infectious diseases associated with climate change.
In this study, Zhang et al. report that a bacterial symbiont residing in the gut of Aedes albopictus mosquitoes protects them from flavivirus infection.
In this Review, Sugrue, Ross and Hill explore recent developments in bacteriocin research, including new discoveries and bioengineering approaches for improved activity, and discuss their application in microbiome modulation and clinical potential.
In this Review, Shepherd, Brockhurst and colleagues explore the clinical evidence in support of four major ecological and evolutionary mechanisms of within-patient antimicrobial resistance emergence in bacteria, and how host niche, bacterial species and antibiotic mode of action combine to govern these mechanisms.
In this study, Carrasco Flores et al. report that the bacterium Mycetocola lacteus protects the microalga Chlamydomonas reinhardtii from the antagonistic activity of Pseudomonas protegens.
In this Journal Club, Ricardo Soto-Rifo discusses a study on intron-containing HIV-1 RNA, revealing its role as a pathogen-associated molecular pattern in myeloid cells, which has implications for immune activation, inflammation and clinical outcomes.
This study shows that a single-stranded RNA phage binds to the Pseudomonas aeruginosa type IV pilus, leading to phage entry into the cell and the detachment of the pilus, which impairs bacterial motility.
In this study, Granton et al. show that biofilm-associated exopolysaccharides produced by Pseudomonas aeruginosa control sickness during lung infection.
In this Review, Chan et al. explore major drug discovery approaches, preclinical antiviral evaluation models, virus-targeting and host-targeting therapeutic strategies, and key treatments currently used in clinical settings for COVID-19.
This Genome Watch article highlights the recent use of large-scale monitoring of natural microbiomes to examine feedback between environmental change and microbial adaptation.