Abstract

Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.

Author affiliations

1. Pamela J. Yeh, Matthew J. Hegreness, Aviva Presser Aiden and Roy Kishony are at the Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
2. Matthew J. Hegreness is also at the Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
3. Aviva Presser Aiden is also at the Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
4. Aviva Presser Aiden and Roy Kishony are also at the School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA

Correspondence to: Roy Kishony^1,4 Email: roy_kishony@hms.harvard.edu

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