Review
Nature Reviews Microbiology 7, 798-812 (November 2009) | doi:10.1038/nrmicro2223
Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs
Mayte Coiras1, María Rosa López-Huertas1, Mayte Pérez-Olmeda1 & José Alcamí1 About the authors
Abstract
HIV-1 can infect both activated and resting, non-dividing cells, following which the viral genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs are established early during primary infection and constitute a major barrier to eradication, even in the presence of highly active antiretroviral therapy. This Review analyses the molecular mechanisms that are necessary for the establishment of HIV-1 latency and their relationships with different cellular and anatomical reservoirs, and discusses the current treatment strategies for targeting viral persistence in reservoirs, their main limitations and future perspectives.
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Author affiliations
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AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.
Email: mcoiras@isciii.es; Email: mrlhuertas@isciii.es; Email: mayteperez@isciii.es; Email: ppalcami@isciii.es
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