Review
Nature Reviews Microbiology 2, 123-140 (February 2004) | doi:10.1038/nrmicro818
Article series: Food Microbiology
Pathogenic Escherichia coli
James B. Kaper1,2, James P. Nataro1,3 & Harry L. T. Mobley2 About the authors
Abstract
Few microorganisms are as versatile as Escherichia coli. An important member of the normal intestinal microflora of humans and other mammals, E. coli has also been widely exploited as a cloning host in recombinant DNA technology. But E. coli is more than just a laboratory workhorse or harmless intestinal inhabitant; it can also be a highly versatile, and frequently deadly, pathogen. Several different E. coli strains cause diverse intestinal and extraintestinal diseases by means of virulence factors that affect a wide range of cellular processes.
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Author affiliations
- Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
- Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
- Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Correspondence to: James B. Kaper1,2 Email: jkaper@umaryland.edu
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