Volume 16 Issue 3, March 2018

This study uses ocean mesocosms to show that climate change can lead to a decoupled increase of cyanobacterial primary production and a collapse of the marine food web.

This month's Genome Watch highlights how the development of new approaches for quantifying the human microbiome may pave the way for better understanding microbial shifts in the context of human health and disease.

In this Review, Bartenschlager and colleagues discuss howFlaviviridaeviruses rewire cellular pathways and co-opt organelles. They compare strategies employed by flaviviruses with those employed by hepaciviruses and discuss the importance of these virus–host interactions in the context of viral replication and antiviral therapies.

Our skin is home to millions of bacteria, fungi and viruses that comprise the skin microbiota. In this Review, Byrd and colleagues discuss recent insights into skin microbial communities, including their composition in health and disease, dynamics between species and interactions with the immune system.

Haldar and colleagues discuss markers and mechanisms of resistance to artemisinins and artemisinin-based combination therapies. They describe the identification ofPlasmodium falciparum Kelch 13 as the primary and, to date, sole causative marker of artemisinin resistance in P. falciparumand explore two proposed resistance mechanisms. They emphasize continuing challenges to improve detection strategies and new drug development strategies.

The interplay between nutrient intake, gut microbial metabolism and microorganism-driven engagement of host receptors contributes to the pathogenesis of cardiovascular disease. In this Review, Brown and Hazen discuss the gut microbial mechanisms that drive cardiovascular disease, with special emphasis on therapeutic interventions.