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This study suggests that the valine residue at position 188 of NS1 has a crucial role in antigenaemia, which is essential for the transmission of Zika virus from mammalian hosts to mosquitoes.
Luethyet al. show that metabolites produced by the gut microbiota can modulate the expression of Campylobacter jejunideterminants that are required for growth, commensalism and virulence.
This month's Genome Watch highlights how whole-genome sequencing (WGS) and epidemiological studies can be combined to explore the link between colonization and infection byKlebsiella pneumoniaein patients who are hospitalised.
Oxidative damage can have a devastating effect on the structure and activity of proteins, leading to cell death. This Review discusses how bacteria repair oxidized proteins and highlights the importance of these repair systems in physiology and virulence.
The human gut is host to a dense microbial community that includes a large bacteriophage population. This Review summarizes bacteria and phage dynamics in health and disease, and considers how phages may be harnessed as novel therapeutics to improve disease outcomes.
Biotrophic fungal plant pathogens secrete protein effectors that support colonization of the host. Here, Kahmann and colleagues discuss new insights into the effector repertoire of smut fungi, the molecular mechanisms whereby effectors ofUstilago maydischange plant cell processes, how the respective genes are regulated and how effectors evolve.
Antibiotic resistance is a global problem that threatens individual and societal well-being. In this Review, Crofts, Gasparrini and Dantas summarize how research has changed from the discovery of resistant bacteria to community-level resistome studies, and they propose future therapeutic and surveillance approaches.
In this Review, Spaan, van Strijp and Torres discuss the implications of the identification of the cellular receptors for theStaphylococcus aureusbi-component leukocidins, the mechanisms of action of the leukocidins, their diverse roles during pathogenesis and their potential as targets for therapeutic interventions.
