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This issue marks the 40th anniversary of the publication of the landmark article by Carl Woese and George Fox in which they proposed the Archaea as a third domain of life.
This study identifies the environmental factors that are associated with changes in bacterial secondary metabolism across natural environments on a metagenome-wide scale.
A recent study revealed howH. pyloriopens cell-to-cell junctions and traverses the gastric epithelium to bind to basolateral integrins, thereby activating the assembly and function of its type IV secretion system.
This month's Genome Watch highlights the variation in gut microbiota across different human communities and explores how this is associated with lifestyle and diet.
The Archaea was recognized as a third domain of life 40 years ago. In this Review, Emeet al. outline a brief history of the changing shape of the tree of life and examine how the recent discovery of diverse archaeal lineages has changed our understanding of the evolutionary relationships between the three domains of life and the origin of the eukaryotic cell.
One of the most prominent features of archaea is the extraordinary diversity of their viruses. In this Review, Prangishviliet al. summarize their morphological diversity, the molecular biology of their life cycles and virus–host interactions, and discuss their evolution and their role in the global virosphere.
In this Review, Stoodley and colleagues discuss current therapeutic strategies and those under development for the treatment of pathogenic biofilms. They explore novel technologies that promise to enhance the efficacy of current therapeutics or provide novel effects and argue that treating biofilm infections requires combination therapies.
The fungal kingdom contains many important plant pathogens, and some species show remarkable variation in genome size and architecture. In this Review, Möller and Stukenbrock summarize key examples from fungal plant pathogen genomics and discuss evolutionary processes in pathogenic fungi in the context of molecular evolution, population genetics and agriculture.
