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Much insight into the workings of the immune system has been garnered from studying patients with primary immunodeficiencies. This article describes the recent discovery of human dendritic cell deficiencies and explains the lessons we can learn from these syndromes.
Ultraviolet radiation from sunlight can modulate immune function by both vitamin D-dependent and -independent mechanisms. The authors discuss the implications of this for understanding whether vitamin D supplementation might benefit patients with autoimmune diseases and allergic asthma, and boost immunity to pathogens.
This article discusses how homeostatic chemokines can shape 'cellular highways' for immune cell trafficking and lymphoid organogenesis. The authors propose that cancer cells exploit these chemokine-driven highways in order to metastasize and thrive at distant tissue sites.
The beneficial impact of exercise on health is indisputable. Here, the authors review the direct and indirect anti-inflammatory effects of exercise and discuss the potential mechanisms involved.
In this Opinion article, Caroline Jefferies and colleagues discuss the evidence in support of a role for TRIM proteins in autoimmune and autoinflammatory disease through their ability to regulate the inflammasome and pro-inflammatory cytokine and interferon production.
Have you ever wondered about the underlying mechanism of why you become lethargic when you have an infection, and why you are more susceptible to infection during times of stressful life circumstances? Here, the reciprocal interactions between behaviour and innate immunity to optimize total organism fitness are discussed.