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Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activation of dendritic cells and thereby contributing to differences in immunity in males and females.
A study in Science reports 10 individuals with pre-TCRα deficiency who have late-onset or no clinical phenotype, which suggests that αβ T cells can develop through a pre-TCRα-independent, non-canonical rescue pathway.
Investigation of neutrophil heterogeneity in tumours reveals the irreversible programming of long-lived, pro-angiogenic neutrophils that drive tumour progression.
The failure of T cell-targeted vaccines for HIV in clinical trials is likely due to impaired degranulation of low-avidity CD8+ T cells in the context of low levels of antigen presentation.
A study published in Immunity shows that the mechanical force experienced by neutrophils migrating across endothelial barriers arms them for better bactericidal activity.
Genetic variants are identified in humans and viruses that influence the development of multiple sclerosis by shaping protective natural killer cell responses.