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A preprint by Zhou et al. shows that the clinical efficacy of immune checkpoint blockade in patients with cancer does not depend on the presence of tumour-draining lymph nodes, as their role is taken over by more distant lymph nodes.
Re-exposure to a previously encountered antigen leads to robust antibody responses and the formation of ‘recall’ germinal centres. A preprint by Schiepers et al. shows that antibody feedback in these germinal centres ensures the maturation of naive B cells that can target escape epitopes.
A preprint by Kim et al. shows that the brain parenchyma can be seeded with age with clonal haematopoiesis-derived monocytes that drive neuropathology.
A preprint by Kwok et al. describes the identification of common neojunction-derived antigens that could serve as targets for ‘off the shelf’ vaccines or adoptive cell therapies for patients with various types of cancer.