News & Comment

Eric Vivier recounts how the initial description of the ITIM motif in FcγRIIB helped to launch the field of inhibitory immune receptors.

Florent Ginhoux reflects on a 2002 paper by Merad and colleagues that challenged the dogma that adult Langerhans cells arise from blood-circulating precursors.

Richard Locksley describes a 2004 study by Margaret McFall-Ngai and colleagues that showed the role of bacterial pattern recognition in driving tissue homeostasis and function.

Ashley Moffett describes a 1995 paper by Colonna and Samaridis that provided the stimulus to understanding the link between NK cells and pre-eclampsia.

Jonathan Sprent describes a 1968 study by Graham Mitchell and Jacques Miller that showed the requirement for T cell–B cell collaboration for antibody production.

Anne Cooke discusses a 1989 paper by Don Mason and colleagues that described a role for adrenal corticosteroids in modulating autoimmune pathology.

Graham Anderson describes a 2001 study by Rodewald and colleagues that provided the first experimental evidence for thymic epithelial cell progenitors.

Linda Sherman describes a 1991 study by Hans-Georg Rammensee and colleagues that defines allele-specific motifs required for the binding of peptides to MHC molecules.

Luke O'Neill describes a 2010 study by Connie Krawczyk, Ed Pearce and colleagues that introduced the Warburg effect to immunologists.

Michael McHeyzer-Williams describes a 1998 study by Avi Kupfer and colleagues that transformed the view of cognate T helper cell–B cell crosstalk.