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Research Highlights
Nature Reviews Immunology 9, 390–391 (1 June 2009) | doi:10.1038/nri2574
Autoimmunity: A new target in multiple sclerosis?
Abstract
A protein that could mediate grey matter pathology in patients with multiple sclerosis has been identified by Derfuss and colleagues. Contactin 2 (encoded by CNTN2), a cell adhesion molecule that is expressed in the juxtaparanodal region of myelinated fibres of the central nervous system (CNS), was identified as a candidate autoantigen using a proteomics approach.
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