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Nature Reviews Immunology 9, 386 (1 June 2009) | doi:10.1038/nri2549

Neuroimmunology: Finding a way into the brain

Elaine Bell

Experimental autoimmune encephalitis (EAE) is an inflammatory demyelinating disease that is used as a model for multiple sclerosis. Both interleukin-17 (IL-17)-producing T helper 17 (TH17) cells and interferon-γ (IFNγ)-producing TH1 cells are thought to be involved in the initiation and development of EAE.