Abstract
The mechanisms by which thymocytes commit to becoming CD4+ T cells and how these cells subsequently can adopt various cell fates are becoming important paradigms of developmental programming. Understanding how such CD4+ T-cell diversity accommodates both immune reaction against various challenges and the suppression of undesirable responses is also revealing new therapeutic options.
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Reiner, S. Decision making during the conception and career of CD4+ T cells. Nat Rev Immunol 9, 81–82 (2009). https://doi.org/10.1038/nri2490
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DOI: https://doi.org/10.1038/nri2490
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