Table of contents
March 2008 Vol 8 No 3
From the editors
p161 | doi:10.1038/nri2288
Research Highlights
Allergy and Asthma: Calling all TH2 cells | PDF (338 KB)
p162 | doi:10.1038/nri2285
Mucosal immunology: Antimicrobial function for IL-22 | PDF (127 KB)
p163 | doi:10.1038/nri2290
In brief
HIV | Immune responses | Regulatory T cells | PDF (96 KB)
p163 | doi:10.1038/nri2292
Allergy and Asthma: Regulation of TGF
1 PINned down | PDF
(372 KB)
p164 | doi:10.1038/nri2286
Vaccines: TBK1 mediates DNA vaccine immunogenicity | PDF (259 KB)
p164 | doi:10.1038/nri2287
In the news
Drug-free after transplantation | PDF (80 KB)
p164 | doi:10.1038/nri2289
Stem cells: Immunosuppression by mesenchymal stem cells | PDF (245 KB)
p165 | doi:10.1038/nri2284
Innate immunity: New role for cathepsin K | PDF (210 KB)
p166 | doi:10.1038/nri2282
Allergy and Asthma: What 'drives' IL-4 versus IL-13 signalling? | PDF (117 KB)
p166 | doi:10.1038/nri2283
In brief
Allergy and asthma | T-cell development | PDF (100 KB)
p167 | doi:10.1038/nri2293
Allergy and Asthma: Mother knows best | PDF (230 KB)
p168 | doi:10.1038/nri2277
B-cell signalling: Synapse formation wRAPped up with help from RAC2 | PDF (230 KB)
p168 | doi:10.1038/nri2291
Focus on: Allergy and asthma
Reviews
Discovering susceptibility genes for asthma and allergy
Donata Vercelli
p169 | doi:10.1038/nri2257
A number of susceptibility genes for asthma and allergy have been identified in recent years. Here, Donata Vercelli discusses these genes and reviews the techniques used by geneticists to identify them. She also highlights the outstanding challenges in the field.
Immunology of asthma and chronic obstructive pulmonary disease
Peter J. Barnes
p183 | doi:10.1038/nri2254
Asthma and chronic obstructive pulmonary disease both involve chronic inflammation of the lungs. But Peter Barnes explains how the inflammatory mediators and cells involved differ between the two diseases and how this affects their responsiveness to corticosteroids and other anti-inflammatory therapies.
Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma
Hamida Hammad & Bart N. Lambrecht
p193 | doi:10.1038/nri2275
In addition to providing a physical barrier, epithelial cells have a role in initiating and maintaining allergic responses to inhaled allergens. As discussed in this Review, epithelial cells can influence the polarization of lung dendritic cells and are themselves influenced by innate and adaptive immune responses during allergic inflammation.
IgE in allergy and asthma today
Hannah J. Gould & Brian J. Sutton
p205 | doi:10.1038/nri2273
Recent advances in the structural determination of IgE and its receptors and associated molecules have provided insight into the functions and regulation of IgE. This is now helping to direct the design of new IgE-targeted therapies for asthma and allergy.
Treatment strategies for allergy and asthma
Stephen T. Holgate & Riccardo Polosa
p218 | doi:10.1038/nri2262
Understanding the mechanisms of allergic inflammation is important for the improvement of current therapies and the development of novel therapies. This Review describes the current therapeutic strategies for allergy and asthma and highlights several innovative future strategies.
Perspective
Opinion
The molecular basis for public T-cell responses?
Vanessa Venturi, David A. Price, Daniel C. Douek & Miles P. Davenport
p231 | doi:10.1038/nri2260
Given that T-cell receptor (TCR) repertoires are randomly generated, how come T cells bearing identical TCRs often dominate the response to an antigen in many individuals? Here, the authors provide a molecular explanation to the conundrum of public T-cell responses.
Corrigendum: Micromanagement of the immune system by microRNAs
Harvey F. Lodish, Beiyan Zhou, Gwen Liu & Chang-Zheng Chen
p238 | doi:10.1038/nri2280
Erratum: Innate immunity: TAMing inflammation
Jennifer Middleton
doi:10.1038/nri2271
