B–cell responses: Pass the parcel | PDF (200 KB)

p657 | doi:10.1038/nri2160

Parasite immunity: Arming T cells early | PDF (148 KB)

p658 | doi:10.1038/nri2165

T cells: Notch and GATA3 join forces | PDF (320 KB)

p658 | doi:10.1038/nri2167

Autoimmunity: Monocytes take centre stage | PDF (116 KB)

p659 | doi:10.1038/nri2166

Immune evasion: Evasive manoeuvres | PDF (319 KB)

p660 | doi:10.1038/nri2157

Immune regulation: Linking integrins, TGF and autoimmunity | PDF (174 KB)

p660 | doi:10.1038/nri2162

Tumour immunology: Innate immune activation enhances tumour immunotherapy | PDF (233 KB)

p662 | doi:10.1038/nri2158

T cells: New regulator of calcium signalling | PDF (361 KB)

p662 | doi:10.1038/nri2169

Chemokines: Dictating migration | PDF (443 KB)

p663 | doi:10.1038/nri2159

Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

Stephen D. Miller, Danielle M. Turley & Joseph R. Podojil

p665 | doi:10.1038/nri2153

Therapeutic strategies that induce antigen-specific immune tolerance without suppressing the ability of the immune system to respond to infectious agents are needed for the treatment of autoimmune diseases. But how might these antigen-specific therapies induce tolerance and are they safe for use in the clinic?

• Abstract
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• PDF (972 KB)

Getting to the site of inflammation: the leukocyte adhesion cascade updated

Klaus Ley, Carlo Laudanna, Myron I. Cybulsky & Sussan Nourshargh

p678 | doi:10.1038/nri2156

To get to the site of inflammation, leukocytes must first adhere to and traverse the blood-vessel wall, events that occur in a cascade-like manner. But what are the exact steps in this cascade and what molecules are involved?

• Abstract
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• PDF (1,126 KB)
• Supplementary information

Calcium signalling in lymphocyte activation and disease

Stefan Feske

p690 | doi:10.1038/nri2152

Recently, two key regulators of calcium influx in lymphocytes were discovered — STIM and ORAI. How this has advanced our understanding of calcium signalling in lymphocytes and the pathological consequences of disruption of this pathway are discussed in this Review.

• Abstract
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• PDF (1,047 KB)
• Supplementary information

Developmental pathways that generate natural-killer-cell diversity in mice and humans

Nicholas D. Huntington, Christian A. J. Vosshenrich & James P. Di Santo

p703 | doi:10.1038/nri2154

Natural killer (NK) cells perform multiple functional activities, including rapid cytokine production and spontaneous cytotoxicity. James Di Santo and colleagues review the evidence that such functional heterogeneity arises from the development of diverse NK-cell subsets with unique biological roles.

• Abstract
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FcRn: the neonatal Fc receptor comes of age

Derry C. Roopenian & Shreeram Akilesh

p715 | doi:10.1038/nri2155

Although best known for its role in mother-to-child IgG transfer, new roles for the neonatal Fc receptor for IgG (FcRn) are emerging. Its role in regulating serum antibody half-life in adults has important implications for autoimmune diseases and antibody-based biologicals.

• Abstract
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Sonic hedgehog signalling in T-cell development and activation

Tessa Crompton, Susan V. Outram & Ariadne L. Hager-Theodorides

p726 | doi:10.1038/nri2151

Hedgehog signalling proteins, and in particular sonic hedgehog, have a role in T-cell development in the thymus and in peripheral T-cell activation, but, as outlined here, some aspects of their functions remain controversial.

• Abstract
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