Table of contents
June 2007 Vol 7 No 6
From the editors
p411 | doi:10.1038/nri2100
Research Highlights
T cells: Human TH17 cells take centre stage
p413 | doi:10.1038/nri2108
Immune regulation: Terminating inflammatory responses
p414 | doi:10.1038/nri2104
Tumour immunology: DCs under the influence
p414 | doi:10.1038/nri2105
In the news
Chitin might hold key to asthma
p414 | doi:10.1038/nri2114
In brief
Reproductive immunology | Evolution | T-cell development
p415 | doi:10.1038/nri2112
Immunodeficiency: Modelling Omenn syndrome
p416 | doi:10.1038/nri2106
Antigen presentation: Planning your route from the start
p416 | doi:10.1038/nri2107
Asthma and allergy: Opposing roles for osteopontin
p417 | doi:10.1038/nri2109
Innate immunity: Pannexin-1: the missing link?
p418 | doi:10.1038/nri2110
Immune regulation: MicroRNAs and the immune response
p418 | doi:10.1038/nri2111
In brief
Natural killer cells | Autoimmunity | Immune regulation
p419 | doi:10.1038/nri2113
Focus on: Cytokines & cytokine therapies
FOREWORD
Cytokines and interventional immunology
David A. Hafler
p423 | doi:10.1038/nri2101
PROGRESS
TH1 cells control themselves by producing interleukin-10
Anne O'Garra & Paulo Vieira
p425 | doi:10.1038/nri2097
Recent studies have shown that the anti-inflammatory cytokine interleukin-10 can be produced by T helper 1 cells. In this Progress article, Anne O'Garra and Paulo Vieira discuss the implications of these studies and the outstanding questions that they now raise.
REVIEWS
Cytokines in the pathogenesis of rheumatoid arthritis
Iain B. McInnes & Georg Schett
p429 | doi:10.1038/nri2094
In a rheumatoid joint, a hierarchical network of cytokines controls immunological processes that promote autoimmunity, chronic inflammation and tissue destruction in rheumatoid arthritis. As proposed in this Review, defining these functional hierarchies may present new opportunities for treating the disease.
TGF
signalling in control of T-cell-mediated self-reactivity
Yuri P Rubtsov & Alexander Y Rudensky
p443 | doi:10.1038/nri2095
This Review describes the recent advances in our understanding of the role of TGF
(transforming growth factor-) signalling in the regulation of T-cell differentiation in the thymus and periphery, with particular emphasis on TGF-mediated control of self-reactive T cells.
SOCS proteins, cytokine signalling and immune regulation
Akihiko Yoshimura, Tetsuji Naka & Masato Kubo
p454 | doi:10.1038/nri2093
In this Review, Akihiko Yoshimura and collegues discuss the most recent advances in our understanding of suppressor of cytokine signalling (SOCS) proteins in the regulation of immunity, their involvement in human diseases and the therapeutic implications of targeting this family of cytokine regulators.
Reviews
The role of junctional adhesion molecules in vascular inflammation
Christian Weber, Line Fraemohs & Elisabetta Dejana
p467 | doi:10.1038/nri2096
Recent studies have elucidated important roles for members of the junctional adhesion molecule (JAM) family in controlling vascular permeability and leukocyte transmigration. Christian Weber and colleagues highlight the role of JAMs as gate keepers in inflammation and vascular pathology.
Perspectives
Opinion
Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development
Leslie J. Berg
p479 | doi:10.1038/nri2091
A number of different non-conventional T-cell lineages with innate phenotypes have been identified. As outlined here, it seems likely that 'innate' T cells develop as a result of interactions with non-classical MHC molecules expressed by haematopoietic cells in the thymus.
Innovation
Integrating epitope data into the emerging web of biomedical knowledge resources
Bjoern Peters & Alessandro Sette
p485 | doi:10.1038/nri2092
In this age of information, keeping up with the literature can be overwhelming for any researcher. The generation of the IEBD – the first epitope-related database that makes complex and context-dependent information on immune epitopes readily accessible and searchable – may help