Table of contents
February 2007 Vol 7 No 2
From the editors
p83 | doi:10.1038/nri2028
Research Highlights
Tolerance: Inducing T-cell tolerance in the gut
p85 | doi:10.1038/nri2029
Regulatory T cells: Staying in character
p86 | doi:10.1038/nri2031
In the news
Spanish secrets
p86 | doi:10.1038/nri2032
Macrophages: Fat gets picky with macrophages
p87 | doi:10.1038/nri2026
HIV: Bigger T-cell response not necessarily better
p88 | doi:10.1038/nri2016
Dendritic cells: DC subsets do it differently
p88 | doi:10.1038/nri2027
Antibody responses: TLR signalling not required
p90 | doi:10.1038/nri2022
Insect immunity: The psidin adventure
p90 | doi:10.1038/nri2030
T-cell development: Getting the balance right
p91 | doi:10.1038/nri2025
Reviews
Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data
Stephan C. Bischoff
p93 | doi:10.1038/nri2018
This Review emphasizes the functional differences between human and murine mast cells, which have often been overlooked in the past, and their implications for studying the role of mast cells in human health and disease.
Transcription factors in myeloid development: balancing differentiation with transformation
Frank Rosenbauer and Daniel G. Tenen
p105 | doi:10.1038/nri2024
Transcription factors are key coordinators of cell fate and therefore they must be tightly regulated to ensure proper differentiation. As described in this Review, dysregulation of myeloid-specific transcription factors causes the block in myeloid differentiation seen in many myeloid leukaemias.
Humanized mice in translational biomedical research
Leonard D. Shultz, Fumihiko Ishikawa and Dale L. Greiner
p118 | doi:10.1038/nri2017
The development of humanized mice over the past few decades has enabled the examination of human haematopoiesis, immunity to infectious diseases, cancer and autoantibodies in mice. But are these mice the key to translational research or is more work required?
Regulation of T-cell activation by the cytoskeleton
Daniel D. Billadeau, Jeffrey C. Nolz and Timothy S. Gomez
p131 | doi:10.1038/nri2021
The T-cell cytoskeleton is a complex intracellular network of structural, adaptor and signalling molecules. This Review discusses recent advances in our understanding of its role in the initiation and maintenance of T-cell activation during antigen-presenting-cell recognition.
Interleukin-7 receptor expression: intelligent design
Renata Mazzucchelli and Scott K. Durum
p144 | doi:10.1038/nri2023
Interleukin-7 is important at many stages in the life of a T cell. Expression of its receptor not only regulates how a T cell responds, but also seems to determine how much interleukin-7 is present in the niche, as explained in this Review.
Perspectives
Opinion
Activating and inhibitory functions of DAP12
Isaiah R. Turnbull and Marco Colonna
p155 | doi:10.1038/nri2014
Although the only signalling motif in the adaptor protein DAP12 is generally thought to transduce activating signals, DAP12 has recently been shown to have inhibitory effects. A model to explain how this might occur is proposed in this Opinion article.
Opinion
Systemic infections and inflammation affect chronic neurodegeneration
V. Hugh Perry, Colm Cunningham and Clive Holmes
p161 | doi:10.1038/nri2015
The immune-system–brain interface is a crucial route for communication between the brain in health and disease and environmental pathogens and toxins. Can systemic infections and inflammation associated with chronic neurodegenerative diseases exacerbate symptoms and drive the progression of neurodegeneration?
