Perspectives
Nature Reviews Immunology 6, 417-423 (May 2006) | doi:10.1038/nri1840
Focus on: Translational immunology
Opinion: Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases
Giuseppe Pantaleo1 About the author & Alexandre Harari1
Abstract
At present, we only have indirect knowledge of the protective role of antigen-specific T cells in human viral infections, and it has been difficult to show a direct correlation between quantitative and qualitative measures of T-cell immunity and virus-associated diseases. However, as described in this Opinion article, recent advances in the characterization of T-cell functions and in the development of standardized T-cell assays have led to the identification of distinct functional signatures of T-cell responses that correlate with levels of viral replication and disease activity.
Author affiliations
- Giuseppe Pantaleo and Alexandre Harari are at the Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland.
Correspondence to: Giuseppe Pantaleo1 Email: giuseppe.pantaleo@chuv.ch
Published online 18 April 2006
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