Review
Nature Reviews Immunology 3, 63-72 (January 2003) | doi:10.1038/nri982
Intestinal IgA synthesis: regulation of front-line body defences
Sidonia Fagarasan1,2 & Tasuku Honjo1 About the authors
Abstract
Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In this review, we summarize recent advances in our understanding of the sites, mechanisms and functions of intestinal IgA synthesis in mice. On the basis of these recent findings, we propose an updated model for the induction and regulation of IgA responses in the gut. In addition, we discuss new insights into the role of IgA in the maintenance of gut homeostasis and into the reciprocal interactions between gut B cells and the bacterial flora.
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Author affiliations
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
- RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Correspondence to: Tasuku Honjo1 Email: honjo@mfour.med.kyoto-u.ac.jp
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