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Type I interferons (IFNs) are best known for their role in antiviral immunity. As discussed in this Review, recent evidence indicates that these cytokines also have an integral role in natural and therapy-induced anticancer immunity. Harnessing the antineoplastic properties of type I IFNs may lead to the development of ever-more effective anticancer therapies.
Innate lymphoid cells (ILCs) are emerging as key regulators of the immune system, with different ILC subsets showing distinct immunological properties. This Review describes the transcriptional mechanisms that regulate the development and function of the different ILC subsets. The authors also discuss the evolving ILC nomenclature.
This Review describes the type I interferonopathies — a set of Mendelian disorders associated with the upregulation of type I interferon activity. The authors explain how defects in key components of innate immune signalling pathways can lead to these diseases and discuss the immunological insights that have resulted from their study.
Although they are better known for their roles in antibody responses, B cells also contribute to immunity by secreting cytokines. Here, the authors discuss the various ways in which B cells can shape the immune response during infection and inflammatory disease by producing both pro-inflammatory and immunosuppressive cytokines.
InvasiveSalmonelladisease is severe and represents a major public health problem worldwide. In this Review, the authors summarize our current understanding of host immunity to Salmonella and compare host genetic data from human and mouse studies.
