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The detection of multiple and often rare T cell specificities is crucial for understanding and therapeutically manipulating T cell responses. In this Perspective article, Daviset al. summarize the latest advances in peptide–MHC multimer technology that have rendered peptide–MHC multimers a valuable tool in both basic and clinical T cell research.
In 1950, the function of the thymus was unknown. Jacques F. A. P. Miller describes how research on its immunological role started and gives an overview of the last 50 years of research on the thymus.
