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Immunotherapy for cancer sometimes has autoimmune complications, and immunotherapy for autoimmunity can compromise microbial defence and immunosurveillance. In this article, Rachel Caspi explores the potential penalties of successful immunotherapeutic approaches and highlights the need for more specific modalities.
Sex-based differences in immune responses can influence the susceptibility to autoimmune and infectious diseases and the efficacy of therapeutic drugs. In this Perspective, Eleanor Fish discusses factors, such as X-linked genes, hormones and societal context, that underlie disparate immune responses in men and women.
In this Perspective article, Michael Starnbach and Nadia Roan discuss the public-health and social impact of sexually transmitted diseases, raising several questions that need to be addressed before these diseases can be conquered.
