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The efficacy of triple therapy forHelicobacter pyloriinfection is often unacceptably low. As a consequence, new first-line treatment alternatives have been proposed. This Viewpoint article discusses the options for improving first-line therapy cure rates either by triple therapy modifications—increasing the length of treatment and/or using high doses of PPIs—or promising new drug schedules such as 'sequential' or 'concomitant' therapies.
The eradication ofHelicobacter pyloriinfection is still a challenge for clinicians. Approximately 5% of patients who undergo two courses of eradication therapy remain infected. The authors of this Viewpoint article discuss the available options for salvage therapy in these patients and the role of antimicrobial susceptibility testing in this setting.
Interferon-based therapy is the cornerstone of treatment for chronic hepatitis C; however, many patients do not respond optimally to current treatment regimens. In this Review, the author considers how interferon-based therapy might be tailored to ensure the best chance of achieving a sustained virological response while preventing over-treatment. The potential of alternative treatment options that will most likely be used in combination with interferon, at least initially, is also discussed.
IBS is a common disorder; however, the available treatment options are unsatisfactory for many patients. A considerable percentage of patients with IBS seek advice from practitioners offering complementary and alternative medical approaches. This Review discusses the literature for alternative mind-body interventions for the treatment of IBS, and addresses the potential relationship of these interventions to the biopsychosocial model and IBS.
Infectious diarrhea is a global health issue that affects billions of individuals annually. The diarrheas can be classified as noninflammatory or inflammatory based on their pathogenesis and clinical presentation. This Review presents our current understanding of the pathogenesis and clinical syndromes of infectious diarrheas, including their epidemiology and the various host factors that protect against enteric infection.
Laparoscopic liver resection (LLR) is a natural extension of minimally invasive surgery. The authors of this Review consider the surgical technique used for LLR, as well as the indications for LLR, before evaluating the short-term and long-term outcomes of LLR by comparing the results of case-matched studies of LLR and open resection for both benign and malignant tumors.
