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Little Brain Big Brain is a biannual meeting organized and attended by young investigators. Since its inception in 1989, this meeting has brought together promising junior researchers in neurogastroenterology. The XVIIth meeting featured the latest basic, clinical and industry research in the field in a special post-pandemic edition.
Gastrointestinal research in Latin America is hampered by a lack of financial support and by biases, affecting research advancement in the region and career development of Latin American scientists. Engagement of the next generation of leaders and established scientists is, therefore, essential to avoid perpetuation of the existing inequalities.
This Review discusses the current and emerging therapeutic landscape for treatment of advanced hepatocellular carcinoma, including molecular-targeted monotherapies, immuno-oncology monotherapies, combination therapies and novel therapeutic approaches.
In this Review, Cowardin, Moore and colleagues discuss advances in our understanding of environmental enteric dysfunction in the context of intestinal adaptation and the gut microbiome during pregnancy, lactation and early childhood.
In this Review, the authors consider various paths to functional cure of chronic hepatitis B (CHB) and the need to individualize therapy of this heterogeneous infection until a therapeutic avenue for all patients with CHB is available.
Intestinal B cell responses are crucial in maintaining gut homeostasis. This Review discusses the role of human intestinal B cells in health and intestinal disease and provides a comprehensive overview of their features.
