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Volume 17 Issue 9, September 2020

The September issue includes a Review on cell death in the gut epithelium, a Viewpoint on the elimination goals for viral hepatitis and a Consensus Statement detailing the horizon in cholangiocarcinoma.

The image shows a mouse small intestine, visualized by nuclear staining, with ribbons of migrating epithelial cells along the intestinal villi during steady-state turnover. Image provided by Denis Krndija, Vignjevic group, Institut Curie, France. The image has been modified for design purposes.

Volume 17 Issue 9

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Editorial

  • The repercussions of the COVID-19 pandemic go far beyond the disease itself, and cannot be overlooked. The gastroenterology and hepatology community has adapted quickly, but resilience and collaboration will be key to address future uncertainty.

    Editorial

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Comment

  • Greater than the coronavirus disease 2019 (COVID-19) crisis, systemic inequity in social determinants of health is the pandemic that has long fostered vulnerability to disease and poor health outcomes in the USA. Our response has major implications for the health of our nations.

    • Darrell M. Gray II
    • Adjoa Anyane-Yeboa
    • Folasade P. May
    Comment

  • Coronavirus disease 2019 (COVID-19) itself and/or the use of hepatotoxic drugs might negatively affect the course and management of patients with pre-existing chronic liver diseases. However, the greatest effect of COVID-19 on liver diseases will be indirect and delayed, resulting from the impending global economic crisis.

    • Jean-Michel Pawlotsky
    Comment

  • The effect of coronavirus disease 2019 (COVID-19) on liver transplantation programmes and recipients is still not completely understood but overall involves the risk of donor-derived transmission, the reliability of diagnostic tests, health-care resource utilization and the effect of immunosuppression. This Comment reviews the effect of COVID-19 on liver transplantation and summarizes recommendations for donor and recipient management.

    • Tommaso Di Maira
    • Marina Berenguer
    Comment

  • The gastrointestinal tract represents a target organ for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting a thorough discussion on the consequences, particularly regarding inflammatory bowel diseases. Here, aspects of gastrointestinal involvement with SARS-CoV-2, the role of viruses as modulators of mucosal immunity and as treatment-related safety hazards, and the current clinical evidence will be discussed.

    • Alexander R. Moschen
    Comment
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Research Highlights

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Viewpoint

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Reviews

  • Evidence points to a crucial role of necroptosis and pyroptosis as important modes of programmed cell death in the intestine in addition to apoptosis. This Review discusses advances in our understanding of apoptosis, necroptosis and pyroptosis as major cell death pathways that can result in pathophysiological outcomes.

    • Jay V. Patankar
    • Christoph Becker
    Review Article
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Consensus Statement

  • Cholangiocarcinoma (CCA) comprises heterogeneous biliary malignant tumours, and their incidence is increasing worldwide. This expert Consensus Statement, endorsed by the ENS-CCA, summarizes the latest advances in CCA, including classification, genetics and treatment, and provides recommendations for CCA management and priorities across basic, translational and clinical research.

    • Jesus M. Banales
    • Jose J. G. Marin
    • Gregory J. Gores
    Consensus Statement Open Access
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