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Pancreaticojejunostomy and pancreaticogastrostomy are both used for reconstruction after pancreaticoduodenectomy; which method is best is still debated. A nationwide multicentre randomized clinical trial that compared these two types of reconstruction has demonstrated that pancreaticogastrostomy is associated with a substantially lower rate of clinically relevant postoperative pancreatic fistula than pancreaticojejunostomy.
Anti-TNF agents are effective drugs available for IBD treatment. However, antibody formation against these drugs hampers clinical effectiveness and increases risk of drug reactions. Knowledge on antibody kinetics and antibody testing is of critical importance to make well-informed decisions about starting, continuing, discontinuing and restarting of anti-TNF agents.
The main therapeutic strategies for GERD are antireflux surgery and pharmacological intervention. The vast majority of patients with GERD receive or prefer medical over surgical therapy. A recent study compared minimal access surgery with medical management and provided 5-year follow up data.
The evolution in surgical technique has somewhat bridged the chasm between need and availability of liver grafts for young children. This study, using data on >2,600 liver transplantations in children <2 years of age from the United Network of Organ Sharing, shows that partial grafts from deceased donors can provide outcomes on par with whole livers.
Compelling evidence indicates that liver regeneration after portal vein occlusion and liver resection promotes tumour progression in patients with colorectal liver metastases. Here, the authors present clinical and experimental data from animal models of colorectal liver metastases pertaining to whether liver regeneration causes proliferation of tumour cells.
Gastrointestinal motility disorders are common in clinical practice. In this Review, the authors present an overview of the currently available gastrointestinal motility and function tests that are used to establish a diagnosis of functional disorders.
Serotonin (5-HT) has been recognized for decades as an important signalling molecule in the gut, but it is still revealing its secrets. Mawe and Hoffman outline the conventional and nonconventional actions of 5-HT, and describe potential therapeutic strategies targeting this molecule and its receptors.
Excessive consumption of alcohol can have serious physical, psychological and social implications. Alcohol dependence is a complex genetic disease, with variants in many different genes affecting a person's risk of becoming dependent on alcohol. Here, the authors discuss the genetic factors underlying this disorder.
The association ofHelicobacter pylori infection with peptic ulcers was published in 1984. Here, Kwong Ming Fock, David Y. Graham and Peter Malfertheiner provide their insights into the advances in H. pyloriresearch over the past 30 years and where research should be targeted in the future.
