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Traditionally, biopsy has been a mainstay and gold standard for the diagnosis of coeliac disease, but a biopsy-sparing approach has been suggested and adopted for the assessment of children in some countries. Here, the authors outline the current diagnostic methods for coeliac disease, discussing the pros and cons of a no-biopsy approach for both adults and children.
Acute gastroenteritis precipitates post-infectious IBS in 10–30% of patients. In this Perspectives, Ghoshal and Gwee discuss evidence of overlap between post-infectious IBS, tropical sprue (which can also develop after acute gastroenteritis) and small intestinal bowel overgrowth, and argue that greater understanding of the links between these conditions will improve understanding of IBS pathogenesis.
Gut microbiota research has rapidly evolved, but has yet to translate fully to the clinic. In this Perspectives, Eamonn Quigley explores whether the gut microbiota could be used as a clinical tool in gastrointestinal disease, providing a note of caution to the hype.
