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The feasibility of long-term organ preservation ex vivo has been reported for the first time with proof of concept in human transplantation. Here, we discuss the possible applications of this novel technology in the clinical setting.
Severe obesity in adolescents affects their health and quality of life. Currently, metabolic and bariatric surgery (MBS) is the only effective intervention, but only a limited number of individuals undergo MBS procedures. Therefore, vigorous research in MBS is a priority for the benefit of adolescents with obesity.
Antibodies targeting tumour necrosis factor have substantially advanced the treatment of paediatric inflammatory bowel disease. Understanding pharmacokinetics and therapeutic drug monitoring has led to increased efficacy and durability of response. Primary non-response is more common in ulcerative colitis than in Crohn’s disease, highlighting the need for alternative biologic agents and oral small molecules.
