Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Isolated studies have suggested that thyroid antibodies may signal an increased risk of miscarriage and/or preterm birth in pregnant women. A recent meta-analysis by Thangaratinam and colleagues concludes that a clear association appears evident. Less certain, however, is whether this pregnancy risk can be reduced with any treatment intervention.
Bone turnover markers are the Cinderella of osteoporosis medicine: despite their great potential, they live a life of neglect and disdain under their glamorous but wicked sister, BMD. With a new position statement, Vasikaran and colleagues are inviting Cinderella to the Prince's ball, for her true worth to be acknowledged. Will it work? Doubts are justified.
The correct diagnosis of a child with a disorder of sex development (DSD) is crucial and can be life-saving. The most challenging situation for the pediatric endocrinologist and for the parents occurs when the sex cannot be determined at birth. A UK task force has now published novel guidelines that delineate the complex program needed for an initial diagnosis.
A recent study of selenium supplementation in patients with mild Graves ophthalmopathy (GO) has demonstrated improvements in associated soft-tissue manifestations of the disease. The findings of this multicenter trial reveal a potential treatment option for the mild form of this vexing disease, which affects the majority of patients with GO.
The authors of this Review integrate contributions of both central and peripheral glucagon-like peptide 1 (GLP-1), which is secreted from the intestine in response to nutrient ingestion, in a model of short-term and long-term control of energy balance. This model is discussed with respect to current GLP-1-based therapies and ongoing research that may help maximize the effectiveness of GLP-1-based treatment of obesity.
A fully functional female reproductive tract is essential for the natural production of offspring; however, developmental abnormalities and disease can cause morbidity and mortality. This Review discusses the normal function of the reproductive tract and some of the major conditions that cause dysfunction, with a focus on endocrine-related dysfunction.
Sustained consumption of high amounts of nutrients replete with appetite-enhancing pro-oxidant advanced glycation endproducts (AGEs) is a crucial link between a positive energy balance and deleterious outcomes, such as insulin resistance and inflammation, and restriction of AGEs in nutrients improves both conditions. This Review focuses on AGEs as novel initiators of oxidative stress that precede rather than result from diabetes mellitus and illustrates the potential therapeutic gains from AGE restriction as an effective, cost-efficient strategy.
Osteogenesis imperfecta, or 'brittle bone disease', is a clinically heterogeneous heritable connective tissue disorder, the causative defects of which are directly related to type I collagen. Human cases and murine models of osteogenesis imperfecta are providing insight into common pathways in dominant and recessive osteogenesis imperfecta, leading to the re-evaluation of its definition, classification and therapeutic approaches.
