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Traumatic brain injury (TBI) can result in hypopituitarism, which in turn affects survival and reduces quality of life. Although this problem is recognized, TBI-related pituitary dysfunction remains underdiagnosed. There is currently no consensus about which patients should be screened; however, the authors of this Viewpoint suggest that case-finding might be the most effective approach.
In boys, delayed puberty can result from transient or permanent (primary or secondary) hypogonadism. As detailed in this Review, patients benefit from short-term or long-term testosterone therapy, enabling them to reach adult body composition. Testosterone can be given intramuscularly or—more recently—in the form of cutaneous gels or patches.
This Review discusses the ways in which obesity in general and adipose tissue in particular might contribute to breast cancer. It details how the balance of adipokines such as leptin and adiponectin might affect tumorigenesis, and the contribution of peritumoral adipose tissue to a cancer-promoting microenvironment.
As well as their huge impact on biological research, molecular techniques are increasingly being applied in a variety of clinical situations. This Review describes several technical aspects and the applicability of such methods for endocrinologists and covers aspects such as genomics and proteomics, detection methods, and experimental genetic manipulation.
