Volume 18 Issue 7, July 2022

It is increasingly clear that pancreatic islet replacement is needed to provide a comprehensive treatment for the growing numbers of patients with type 1 diabetes mellitus. Advances from the past year suggest that this goal might now be within reach.

Stem cells in the pituitary master gland remain mystifying; moreover, they have hardly been explored in humans. A new study applied transcriptome and chromatin accessibility profiling at single-cell resolution to human postmortem pituitary glands from individuals of different ages, thereby providing insights into the heterogeneity and regulatory mechanisms of the projected human pituitary stem cell population.

By identifying a new means of communication between endothelial cells and adipocytes, researchers provide evidence that the endothelial cells actively provoke lipid release from adipocytes to support capillary growth. This crosstalk ultimately helps to maintain metabolic health in obesity.

This article discusses the current understanding of the genetics of autoimmune Addison disease and outlines the autoimmune mechanisms that could underlie the effects on the adrenal cortex.

Prevalence of type 2 diabetes mellitus (T2DM) is increasing substantially in India and China. This Review discusses the epidemiology, phenotypes and pathogenesis of T2DM in India and China and evaluates options for optimal pharmacological management.

This Review discusses the role of epigenetic mechanisms in the development of type 2 diabetes mellitus and in the regulation of body weight in humans. How epigenetics might help the development of precision medicine is outlined.