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It is commonly accepted that dietary habits and cardiometabolic disorders are connected to the composition of the gut microbiota. However, can we really generalize and predict health by screening faecal microorganisms? A study has taken the plunge and identified a vast range of correlations supporting this possibility.
This Review focuses on physiological and pathological aspects of the hormonal regulation of biomineralization, which is crucial for skeletal health during adulthood, fetal and neonatal development and pregnancy. The role of mineral intake, serum concentrations of mineral and hormonal regulators of biomineralization are highlighted.
White adipocyte metabolism is important for the regulation of systemic metabolism and is often dysregulated in various conditions, such as cancer and type 2 diabetes mellitus. In this Review, Langin and colleagues provide an overview of lipid metabolism in white adipocytes and the related metabolism of glucose and discuss how these pathways provide therapeutic targets in metabolic disorders.
Alterations of RET kinase have been found in diverse thyroid cancer subtypes. This Review describes the RET mutations and gene fusions that can occur in thyroid cancer and highlights specific RET kinase inhibitors that are in clinical and preclinical use.
Understanding mineralized tissues, such as bone and cartilage, in health and disease requires a thorough knowledge of their structures. This Perspective proposes a new imaging and characterization strategy for mineralized tissue research that utilizes focused ion beam-scanning electron microscopy.
