Volume 16 Issue 8, August 2020

Available interventions for adolescents with obesity are based on behavioural therapy and lifestyle modification. A new randomized, controlled trial provides evidence of efficacy of a pharmacological therapy, liraglutide, for weight control in adolescent obesity. The indications for more widespread use of this medication in clinical practice are under discussion.

Kisspeptin neurons in the hypothalamus exert key regulatory control over reproduction and are subjected to tight control by metabolic factors. This Review highlights the mechanisms by which kisspeptin neurons undergo metabolic regulation, from early developmental stages through to adulthood.

Creatine is well known to have a key role in energy buffering; however, new work is showing that creatine also has roles in diverse cell types and physiological conditions that are distinct from this classic role. This Review discusses the role of creatine in adipocyte thermogenesis, immunity and cancer cell survival.

High doses and long-term use of glucocorticoids lead to an important and common iatrogenic complication, glucocorticoid-induced osteoporosis. This Review outlines our current understanding of the pathogenesis of glucocorticoid-induced osteoporosis and discusses treatment options.

Dumping syndrome is a frequent complication of oesophageal and gastric surgery, as well as bariatric surgery; however, guidance on how to manage patients with this condition is lacking. In this Evidence-based guideline, the authors use a Delphi consensus process to develop uniform guidance for the definition, diagnosis and management of dumping syndrome.