Resistance to thyroid hormone: one of several defects causing reduced sensitivity to thyroid hormone

Samuel Refetoff

doi:10.1038/ncpendmet0703 | Full Text | PDF (103K)

Obesity—personal choice or public health issue?

Michelle M Mello

The prevalence of obesity in the US is increasing at a rapid rate. The author of this Viewpoint asks whether the government should introduce public health policies to address the obesity epidemic and, if so, what are the justifications for such intervention in the personal lifestyle choices of the American public?

doi:10.1038/ncpendmet0695 | Full Text | PDF (126K)

Changes in the management of children with intersex conditions

Milton Diamond and Hazel G Beh

Three broad recommendations have been made for the management of children with intersex conditions: halt all infant cosmetic genital surgery until evidence-based guidelines are available; conduct further research on the necessity of such surgery; and practice complete honesty with parents and patients. The authors discuss whether clinical practice has changed in response to these recommendations.

doi:10.1038/ncpendmet0694 | Full Text | PDF (124K)

Diabetes and CVD: impact of antidiabetic agents on morbidity and mortality

doi:10.1038/ncpcardio1046 | Full Text | PDF (68K)

Cardiovascular disease risk in women with polycystic ovary syndrome

doi:10.1038/ncpendmet0682 | Full Text | PDF (68K)

Conservative management of congenital hyperinsulinism shows good neurological outcomes

doi:10.1038/ncpendmet0683 | Full Text | PDF (73K)

Increased fracture risk in HIV-positive women

doi:10.1038/ncpendmet0688 | Full Text | PDF (68K)

Gamma knife radiosurgery is safe and effective in patients with acromegaly

doi:10.1038/ncpendmet0684 | Full Text | PDF (68K)

Desmopressin stimulation provides accurate differential diagnosis of Cushing's syndrome

doi:10.1038/ncpendmet0685 | Full Text | PDF (73K)

Oral contraception use reduces overall cancer risk in older women

doi:10.1038/ncpendmet0686 | Full Text | PDF (68K)

Imaging-based detection of metastases in patients with medullary thyroid carcinoma

doi:10.1038/ncpendmet0690 | Full Text | PDF (68K)

Increased fracture risk in women with CVD

doi:10.1038/ncpendmet0689 | Full Text | PDF (68K)

Nonfunctioning pituitary adenomas: the consequences of a 'watch and wait' approach

doi:10.1038/ncpendmet0691 | Full Text | PDF (68K)

Discontinuation of therapy in men with idiopathic hypogonadotropic hypogonadism

doi:10.1038/ncpuro0948 | Full Text | PDF (73K)

Diabetes increases risk of mortality in patients with acute coronary syndromes

doi:10.1038/ncpcardio1028 | Full Text | PDF (68K)

Does estrogen therapy reduce coronary artery calcification in postmenopausal women?

Régine Sitruk-Ware

doi:10.1038/ncpendmet0668 | Full Text | PDF (129K)

Transsphenoidal surgery for Cushing's disease—importance of histopathology for prediction of outcome

Francesco Cavagnini and Francesca Pecori Giraldi

doi:10.1038/ncpendmet0670 | Full Text | PDF (126K)

Patients with diabetes—to whom should one offer statin treatment?

Amanda Adler

doi:10.1038/ncpendmet0671 | Full Text | PDF (124K)

Is long-acting repeatable octreotide an effective primary therapy for patients with acromegaly?

Vivien S Bonert

doi:10.1038/ncpendmet0672 | Full Text | PDF (125K)

Is yearly intravenous zoledronic acid comparable to weekly oral alendronate for postmenopausal osteoporosis?

Maria Luisa Brandi

doi:10.1038/ncpendmet0673 | Full Text | PDF (126K)

Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer

Andrew V Schally, Jozsef L Varga and Jörg B Engel

Growth-hormone-releasing hormone (GHRH) and its receptors are expressed in a wide variety of normal and malignant tissues. This article describes various GHRH antagonists, their mechanisms of action, and in vivo studies. These antagonists are a promising potential therapy for a wide range of cancers, and perhaps other diseases.

doi:10.1038/ncpendmet0677 | Full Text | PDF (377K)

Drug Insight: eplerenone, a mineralocorticoid-receptor antagonist

Frances McManus, Gordon T McInnes and John MC Connell

Aldosterone has many roles beyond water and sodium homeostasis, including blood pressure regulation. It is important in development of heart failure. Aldosterone binds the mineralocorticoid receptor. Eplerenone is a very specific antagonist of this receptor, and is used to treat heart failure and hypertension. It has many other potential applications, including management of ischemic heart disease and preventing progression of nephropathy.

doi:10.1038/ncpendmet0676 | Full Text | PDF (248K)