Table of contents

November 2006 Volume 2 No 11

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Editorial

Is it possible to predict the onset of Graves' disease?

Nobuyuki Amino

589

doi:10.1038/ncpendmet0326 | Full Text | PDF (70K)


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Viewpoints

Genetic predictors of ovarian hyperstimulation syndrome in women undergoing in vitro fertilization

Anne Delbaere, Guillaume Smits, Gilbert Vassart and Sabine Costagliola

590

Ovarian hyperstimulation syndrome (OHSS) is a complication of pregnancy caused by an excessive response to follicle-stimulating hormone (FSH). OHSS can arise spontaneously or after exogenous FSH administration during in vitro fertilization procedures. Novel genetic predictors of OHSS, including mutations and polymorphisms of the FSH receptor, are described in this Viewpoint.

doi:10.1038/ncpendmet0319 | Full Text | PDF (97K)

Management of obesity in Prader–Willi syndrome

Merlin G Butler

592

Prader–Willi syndrome (PWS) is associated with uncontrolled appetite and morbid obesity. Management of PWS is particularly challenging and requires the involvement of both the family and health-care providers, as well as the affected individual. In this Viewpoint the efficacy of the strategies currently used to control obesity in PWS is discussed.

doi:10.1038/ncpendmet0320 | Full Text | PDF (90K)


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Research Highlights

No link between androgen receptor gene polymorphisms and heart disease

594

doi:10.1038/ncpendmet0288 | Full Text | PDF (78K)

The effect of lesion type on central precocious puberty

594

doi:10.1038/ncpendmet0303 | Full Text | PDF (78K)

No need to treat obese children with hyperthyrotropinemia

594

doi:10.1038/ncpendmet0304 | Full Text | PDF (87K)

Estrogen, leptin and exercise in premenopausal women

595

doi:10.1038/ncpendmet0305 | Full Text | PDF (79K)

Men with high estradiol levels have a low risk of cardiovascular disease

595

doi:10.1038/ncpendmet0306 | Full Text | PDF (87K)

Is it time to ditch the low-fat, high-carbohydrate weight-loss diet?

596

doi:10.1038/ncpendmet0307 | Full Text | PDF (76K)

Jury still out on the benefits and safety of multivitamin and mineral supplements

596

doi:10.1038/ncpendmet0308 | Full Text | PDF (76K)

Instant vertebral assessment can diagnose vertebral fracture in postmenopausal women

596

doi:10.1038/ncpendmet0309 | Full Text | PDF (85K)

Women with low BMD should not be excluded from screening mammography

597

doi:10.1038/ncpendmet0310 | Full Text | PDF (78K)

Chromium supplements could benefit patients with type 2 diabetes

597

doi:10.1038/ncpendmet0311 | Full Text | PDF (87K)

Duration of diabetes is a key factor in ESRD and mortality

598

doi:10.1038/ncpendmet0312 | Full Text | PDF (79K)

Intensive diabetes-management programs might not improve patient outcomes

598

doi:10.1038/ncpendmet0313 | Full Text | PDF (86K)

Preoperative nutritional status of Roux-en-Y gastric bypass candidates

599

doi:10.1038/ncpgasthep0587 | Full Text | PDF (79K)

Oxcarbazepine increases the levels of some androgens

599

doi:10.1038/ncpneuro0311 | Full Text | PDF (79K)


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Practice Points

Does denosumab improve low BMD in postmenopausal women?

Murray J Favus

600

doi:10.1038/ncpendmet0328 | Full Text | PDF (93K)

HIV and the thyroid—what every practicing endocrinologist needs to know

Ann Danoff

602

doi:10.1038/ncpendmet0322 | Full Text | PDF (93K)

Are elevated aldosterone levels associated with refractory hypertension?

Lawrence R Krakoff

604

doi:10.1038/ncpendmet0314 | Full Text | PDF (94K)

Preventing fractures—how good are we really?

Ego Seeman

606

doi:10.1038/ncpendmet0316 | Full Text | PDF (92K)

What is the pathogenesis of hyponatremia after subarachnoid hemorrhage?

Salvatore Benvenga

608

doi:10.1038/ncpendmet0302 | Full Text | PDF (92K)

How beneficial is radioiodine therapy for treating distant metastases from thyroid carcinoma?

Ernest L Mazzaferri

610

doi:10.1038/ncpendmet0317 | Full Text | PDF (94K)


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Reviews

The role of oxyntomodulin and peptide tyrosine–tyrosine (PYY) in appetite control

Katie Wynne and Stephen R Bloom

612

Oxyntomodulin and peptide tyrosine–tyrosine are gut hormones that act as satiety signals and decrease food intake; oxyntomodulin may also increase energy expenditure. Studies in humans show these effects in normal-weight and overweight volunteers; these peptides and their derivatives are, therefore, potential therapies for conditions such as obesity.

doi:10.1038/ncpendmet0318 | Full Text | PDF (193K)

Mechanisms of Disease: regulation of glucocorticoid and receptor levels—impact on the metabolic syndrome

Selma F Witchel and Donald B DeFranco

621

Most tissues express glucocorticoid receptors but tissue-specific modulation of this receptor affects homeostasis, immune responses and cell differentiation mediated by glucocorticoids. This Review describes the mechanisms involved—including nucleocytoplasmic shuttling, degradation and gene polymorphisms—and details the effects on the metabolic syndrome.

doi:10.1038/ncpendmet0323 | Full Text | PDF (514K)

Mechanisms of Disease: adrenocortical tumors—molecular advances and clinical perspectives

Jérôme Bertherat, Lionel Groussin and Xavier Bertagna

632

Many of the genes involved in development of adrenocortical tumors have been identified, and their effects on well-known signaling pathways (for example those involving cyclic AMP or beta-catenin and Wnt) have been investigated. These advances have important implications for understanding disease development, identifying molecular markers and designing new therapeutic strategies for adrenocortical tumors.

doi:10.1038/ncpendmet0321 | Full Text | PDF (287K)


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Case Study

Continuing Medical Education

Cushing's syndrome caused by an occult source: difficulties in diagnosis and management

Ashley B Grossman, Philip Kelly, Andrea Rockall, Satya Bhattacharya, Ann McNicol and Tara Balwick

642

doi:10.1038/ncpendmet0327 | Full Text | PDF (205K)


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