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Viewpoint
Nature Reviews Endocrinology 1, 60–61 (1 December 2005) | doi:10.1038/ncpendmet0045
Do all patients with RET mutations associated with multiple endocrine neoplasia type 2 require surgery?
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Abstract
Screening for mutations in the RET proto-oncogene has revolutionized management of multiple endocrine neoplasia type 2 (MEN2), although controversy still exists regarding the timing and extent of surgical intervention. This Viewpoint discusses the relationship between genotype and phenotype in MEN2 and describes strategies to determine the appropriate age for patients to undergo thyroidectomy.
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