Table of contents
November 2005 Volume 1 No 1
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Viewpoints
Pituitary adenomas: is Gamma Knife® radiosurgery safe?
2Gamma Knife® radiosurgery is widely used to treat patients with pituitary adenoma. Although this procedure has a high success rate, it is also associated with potential complications, including visual dysfunction. This Viewpoint considers whether the benefits of Gamma Knife® surgery outweigh the risks.
Mineralocorticoid-receptor blockade, hypertension and heart failure
4Hypertension and heart failure can be treated with mineralocorticoid-receptor antagonists, although therapy is associated with an increased incidence of hyperkalemia. Data from three influential clinical trials—RALES, EPHESUS and 4E—are described and the findings discussed within the context of mineralocorticoid-receptor biology.
Research Highlights
Testosterone increases extracellular fluid in hypopituitary men
6Laparoscopic mini-gastric bypass is simple and safe
6Role of ACE inhibitors in patients with glycogen storage disease type 1
7Rosiglitazone improves insulin resistance in polycystic ovary syndrome
7GHRH antagonists: a novel therapy for non-Hodgkin's lymphoma
8Pregnancy linked to decreased insulin secretion in cystic fibrosis
9Plasma adiponectin levels do not predict the risk of CHD
9Thyroid-stimulating hormone modulates gene expression in vivo
10Parathyroid hormone followed by alendronate maintains BMD gains in osteoporosis patients
10A new treatment algorithm for radioiodine treatment of children with thyroid cancer
11Practice Points
Is hypopituitarism a common event following traumatic brain injury?
12Is long-term methimazole therapy as effective as radioiodine for treating hyperthyroidism?
14Does metabolic syndrome impact on outcome after acute myocardial infarction?
16Is combined therapy with levothyroxine and liothyronine effective in patients with primary hypothyroidism?
18Reviews
Biologic actions and therapeutic potential of the proglucagon-derived peptides
22Proglucagon-derived peptides from the pancreas and gut regulate various aspects of energy homeostasis, with many potential therapeutic applications—glucagon is used to treat hypoglycemia, and researchers are testing glucagon antagonists and glucagon-derived peptide 1 receptor (GLP-1R) agonists to treat type 2 diabetes, and a GLP-2 analogue to treat short-bowel syndrome.
doi:10.1038/ncpendmet0017 | Full Text | PDF (335K)
Thyroid-hormone therapy and thyroid cancer: a reassessment
32Thyroid-cell proliferation depends on TSH; suppression of TSH with levothyroxine decreases progression and recurrence rates for thyroid cancer. Long-term TSH suppression benefits patients at high risk of cancer recurrence but not low-risk patients, so TSH levels should be targeted accordingly.
doi:10.1038/ncpendmet0020 | Full Text | PDF (214K)
Clinical practice in Turner syndrome
41Turner syndrome is a common genetic disorder that leads to a wide range of endocrine and other abnormalities, but no firm diagnostic guidelines exist. Growth hormone and hormone-replacement therapy can correct the major features, but the long-term consequences of such treatments are unknown.
doi:10.1038/ncpendmet0024 | Full Text | PDF (492K)
Case Study
Severe hypertriglyceridemia with a history of treatment failure
53doi:10.1038/ncpendmet0025 | Full Text | PDF (158K)
