PrimeViews in 2021

This PrimeView highlights the steps in the coagulation cascade that are impaired in haemophilia, a disorder caused by mutations in the genes encoding coagulation factors VIII or IX.

This PrimeView accompanies the Primer by Pober, Kozel and colleagues and highlights the epidemiology, pathophysiology, diagnosis, screening, management and quality of life of individuals with Williams syndrome.

Microscopic colitis (MC) is an inflammatory bowel disease that causes persistent watery diarrhoea. This PrimeView highlights the epidemiology, mechanisms, diagnosis and management of MC.

This PrimeView highlights the different types of contact dermatitis (a common inflammatory skin disease) and some of the most common allergens or irritants that can cause it.

This PrimeView accompanies the Primer by van Spronsen and colleagues and highlights the epidemiology, pathophysiology, diagnosis, screening, management and quality of life of individuals with phenylketonuria.

This PrimeView highlights the pathophysiology of Alzheimer disease, a neurodegenerative disorder that manifests as cognitive impairment, and accompanies the Primer on Alzheimer disease by Knopman and colleagues.

This PrimeView highlights the pathophysiology of age-related macular degeneration, and summarizes the diagnosis, management, epidemiology and outlook of this disorder. It accompanies the Primer on this topic by Fleckenstein and colleagues.

This PrimeView highlights the complex interactions between both prothrombotic and antithrombotic mechanisms that underlie trauma-induced coagulopathy.

This PrimeView accompanies the Primer by Pawlik and colleagues and highlights the epidemiology, pathophysiology, diagnosis, screening, management and the quality of life of patients with liver metastases.

This PrimeView highlights the epidemiology of pneumonia, a respiratory infection that can be caused by pathogens whose prevalence varies depending on the geographical area and the site of acquisition (community or healthcare settings).

This PrimeView highlights the pathophysiology of tension-type headache and accompanies the Primer article on this topic by Ashina and colleagues.

This PrimeView highlights the mechanisms of carcinogenesis of gastrointestinal stromal tumours, and summarizes the epidemiology, diagnosis, management, quality of life and outlook of patients with this disease. It accompanies the Primer on this topic by Blay and colleagues.

This PrimeView describes the types of adrenal insufficiency, its epidemiology, mechanisms, diagnosis and management as well as highlights the specific strategies to prevent and treat adrenal crises.

This PrimeView accompanies the Primer article on Cannabis use and cannabis use disorder by Connor and colleagues, and highlights the future research priorities for this disorder.

This PrimeView highlights the treatment of Duchenne muscular dystrophy, a genetic disorder that is caused by mutations in DMD that prevent production of the muscle isoform of dystrophin.

Penile cancer is a rare disease for which early diagnosis is crucial to avoid poor prognosis and outcomes. This PrimeView highlights the epidemiology, diagnosis, mechanisms and management of penile cancer and accompanies the Primer on this topic by Thomas and colleagues.

Prostate cancer is the second most common cancer in men. This PrimeView describes epidemiology, diagnosis and management of the disease and highlights the mechanisms of its development.

The incidence of Hepatocellular carcinoma (HCC) is increasing worldwide. This PrimeView describes the epidemiology, mechanisms and diagnosis of HCC as well as highlights the major advancements in its management.

Small-cell lung cancer is a rapidly proliferating cancer with a poor prognosis, and is strongly associated with exposure to tobacco carcinogens. This PrimeView highlights the epidemiology, pathogenesis, diagnosis and management of the disease.

Tendinopathy describes a spectrum of changes that occur in a tendon, leading to pain and impaired function. This PrimeView accompanies the Primer article on Tendinopathy by Millar and colleagues and highlights its epidemiology, mechanisms, diagnosis, and management.