PrimeViews in 2019

This PrimeView highlights the risk factors for diabetic neuropathy, which is the most prevalent complication of diabetes mellitus.

In the management of ST-segment elevation myocardial infarction, it is essential that reperfusion therapy (which aims to restore blood flow in the occluded coronary artery) is performed as soon as possible, to limit tissue ischaemia and infarct size.

This PrimeView highlights the signs of male hypogonadism through the lifespan and describes the key underlying causes of the condition in boys and men.

Barrett oesophagus (BE) is a precursor lesion to oesophageal adenocarcinoma. This PrimeView discusses the epidemiology, pathogenesis, diagnosis and treatment of BE.

Various causes can underlie dilated cardiomyopathy, including genetic mutations, infections and inflammation, but the common end result is dilation of the ventricles, which leads to impaired contractility and heart failure.

This PrimeView accompanies the Primer on Myasthenia gravis by Gilhus et al. and focuses on disease mechanisms.

This PrimeView highlights oesophageal atresia, a congenital abnormality of the oesophagus that requires surgical reconstruction soon after birth.

This illustrated PrimeView discusses the epidemiology of spinocerebellar ataxias, the complex mechanisms underlying them and how they are diagnosed and managed in the clinic.

This PrimeView accompanies the Primer by Rockson and colleagues and highlights the available therapies for lymphoedema, which is a frequent complication of cancer treatment that can severely affect quality of life.

Acromegaly is a hormonal disorder that is usually caused by a growth hormone-secreting pituitary adenoma. This PrimeView highlights the pathogenesis, diagnosis and management of acromegaly.

Acute respiratory distress syndrome (ARDS) is the rapid onset of noncardiogenic pulmonary oedema, hypoxaemia and the need for mechanical ventilation in hospitalized patients. This PrimeView highlights the pillars of treatment for patients with ARDS.

This PrimeView highlights the mechanisms underlying pulmonary alveolar proteinosis, a syndrome characterized by abnormal accumulation of alveolar surfactant in the lungs and dysfunction of the alveolar macrophages.

Radiotherapy can be used with curative intent or to palliate symptoms in many patients with cancer. This PrimeView explores how irradiation to nearby adjacent tissues can be associated with short-term toxicity and long-term consequences.

This PrimeView accompanies the Primer on Medulloblastoma by Pfister et al., and describes the quality of life issues faced by patients with this disease.

This illustrated PrimeView provides an overview of the epidemiology, clinical features, cellular mechanisms and management of the main forms of Kaposi sarcoma.

The WHO defines female subfertility as failure to achieve a clinical pregnancy after 12 months of regular intercourse or due to impairment of a woman’s capacity to reproduce. This PrimeView highlights some of the mechanisms that may contribute to this condition.

This PrimeView highlights the current treatment of brain metastases, which occur in approximately 20% of patients with cancer.

This PrimeView highlights the pathophysiology of coeliac disease, a systemic disorder driven by the ingestion of dietary gluten and characterized by diverse intestinal and extraintestinal manifestations.

This illustrated PrimeView highlights rhabdomyosarcoma epidemiology, disease mechanisms, diagnosis, risk-based disease management, and prevention of late treatment effects.