PrimeViews in 2017

Hepatitis C virus (HCV) infection can cause acute and chronic liver inflammation — hepatitis C — and can result in liver cirrhosis and hepatocellular carcinoma. This PrimeView focuses on the development of direct-acting antiviral agents, which have revolutionized the treatment of HCV infection.

Neurofibromatosis type 1 is caused by mutations in the NF1 tumour suppressor gene. The clinical manifestations of neurofibromatosis type 1 are highlighted in this PrimeView and can include defects in the skin, nervous system and bone.

This PrimeView highlights how a diagnosis of neuropathic pain is reached, which is important to provide appropriate treatments.

This illustrated PrimeView accompanies the Primer on narcolepsy by Kornum and colleagues, and focuses on the diagnosis and clinical manifestations of narcolepsy type 1 (also referred to as narcolepsy with cataplexy).

Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by motor tics and at least one vocal tic. Tics have an onset in childhood and improve with increasing age. This PrimeView focuses on the clinical characteristics and the impact that GTS has on quality of life.

Chronic lymphocytic leukaemia (CLL) is a B cell malignancy. This PrimeView focuses on the mechanisms underlying the development of CLL, including genetic alterations, B cell receptor signalling and interactions within the tumour microenvironment.

Congenital hearing loss affects up to 3 per 1,000 children; it can severely impair speech and reading skills and emotional and cognitive development. This PrimeView highlights the importance of neonatal hearing screening programmes and early diagnosis in the management of this condition.