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Calcific aortic stenosis (AS) results from the thickening and calcification of valve leaflets and subsequent obstruction of blood-flow across the aortic valve This PrimeView highlights the management of AS, for which the only treatment is aortic valve replacement.
This PrimeView highlights the surgical interventions to treat kidney stones, which can develop when the urine becomes supersaturated with respect to a given mineral.
IgA nephropathy is a common glomerulonephritis that is probably triggered by the aberrant glycosylation of IgA1, which is recognized as an autoantigen. This PrimeView highlights the plausible mechanisms underlying the disease, as well as how patients are managed.
Erectile dysfunction is the inability to achieve or maintain an erection for satifactory sexual performance, which as a considerable impact on quality of life. This PrimeView highlights the treatment options for this condition.
Post-transplant lymphoproliferative disorders (PTLDs) show some similarities with classic lymphomas in the general population, but occur only in immunosuppressed individuals following transplantation. This PrimeView highlights the involvement of Epstein–Barr Virus infection as an aetiological trigger in many PTLDs.
Patent foramen ovale (PFO) is the consequence of failed closure of the foramen ovale, a normal structure that is present in the fetus to direct blood flow directly from the right to the left atrium, bypassing the pulmonary circulation.
A single episode or repeated episodes of acute rheumatic fever can severely damage the heart valves, leading to rheumatic heart disease — a chronic condition that can cause heart failure. This PrimeView highlights that these conditions are most common in developing countries and are strongly related to socioeconomic disadvantage.
Cerebral palsy is a clinical description of children and adults who share features of motor dysfunction as a consequence of a non-progressive brain injury. This PrimeView focuses on the heterogeneous presentation of the movement disorder, depending on the location of the brain injury.
