Review
Nature Reviews Drug Discovery 4, 321-330 (April 2005) | doi:10.1038/nrd1692
Subject Category: Model organisms
Model organisms: Chemistry-to-gene screens in Caenorhabditis elegans
Andrew K. Jones1, Steven D. Buckingham1 & David B. Sattelle1 About the authors
Abstract
The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.
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Author affiliations
- MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
Correspondence to: David B. Sattelle1 Email: david.sattelle@anat.ox.ac.uk
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