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Roche is one of the few pharmaceutical companies that has stayed firmly committed to research and development for central nervous system disorders. Here, Luca Santarelli, Senior Vice President and Head of Neuroscience Research and Early development, discusses why.
Chris Lipinski, originator of the 'rule of five' guidelines for predicting the oral bioavailability of drug candidates, discusses their impact as well as efforts to expand drug-like chemical space and drug repositioning initiatives.
Mark McClellan, Director of the Brookings Institution's health care reform centre, discusses the need for better metrics to measure the health of biomedical innovation.
Jane Reese-Coulbourne, executive director of the Reagan-Udall Foundation, discusses how long-awaited federal funding will be used to support the FDA's regulatory science.
Trevor Mundel, new President of Global Health at the Bill & Melinda Gates Foundation, discusses his plans for a high-throughput approach to translational research.