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The effectiveness of renal cryoablation is difficult to determine in the absence of specific clinical research protocols, and the role of this technique in the treatment of small renal masses cannot yet be defined as a paradigm shift.
Hemopoietic stem-cell transplantation (HSCT) remains an important curative therapy for many malignant and non-malignant conditions and its use worldwide is increasing. Although many advances have been made in this field, graft-versus-host disease (GvHD), or its treatment, is responsible for causing high morbidity and mortality in patients potentially cured from their primary disease. This review summarizes the successful treatment of steroid refractory-dependent acute and chronic GvHD with extracorporeal photochemotherapy.
Locoregional techniques have become the mainstay of therapy for patients with unresectable hepatocellular carcinoma (HCC). These include catheter-based approaches and locoregional ablative techniques. These therapies are mainly utilized for palliation, but have also been used with curative intent. This review outlines the current status of the most commonly used image-guided loco-regional interventions for the treatment of HCC, and describes recent research and advances related to image-guided interventions for HCC.
There is extensive in vitro and in vivo preclinical evidence that bisphosphonates, particularly zoledronic acid and ibandronate, have antitumor activity, can reduce skeletal tumor burden, and might potentially have antitumor activity outside the bone microenviroment. The authors of this review highlight the importance of correct sequencing of these compounds when used in conjunction with cytotoxic drugs, targeted molecular therapies, and radiotherapy. The need to identify new molecular targets of nitrogen-containing bisphosphonates is discussed in this context and the correct sequence and the timing of drug administration could help drive molecular research and determine the efficacy of the therapy, both in advanced disease and in the adjuvant setting.
